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Repatha New Powerful Cholesterol-Lowering Drug Prevents Heart Attack

Repatha New Powerful Cholesterol-Lowering Drug Prevents Heart Attackā€

However, Prof Sever said: "They will probably not [replace statins], there are an bad lot of people with really quite high cholesterol out there and we'll probably need more than one drug to get their levels down". It also helps with other heart-related problems.

"So we expect that this drug also will be embraced by the medical community" and incorporated into clinical guidelines, Levy said.

"We appear to have found a versatile, easy-to-take, safe, treatment that provides sustained lowering of cholesterol levels and is therefore likely to reduce the risk of cardiovascular disease, heart attacks, and stroke, ? said Professor Kausik Ray from School of Public Health at Imperial". Based on this analysis, Amgen believes that while net prices in the market are variable, they do already exist in a value-based range. They followed-up these people for two years, from 2013 to 2015.

And when the researchers looked at the most serious possible outcomes for heart patients - deaths, heart attacks and strokes - the study showed a 20 reduction of those events.

The results of a new study show that, when added to statin therapy, evolocumab reduced LDL cholesterol levels by 59% from baseline levels compared with placebo.

FOURIER is the first outcomes trial to read out for the PCSK9 class. Sanofi and Regeneron are conducting their own study, dubbed ODYSSEY, to test Praluent's cardiovascular benefit.

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Amgen presented the detailed results from EBBINGHAUS at a Late-Breaking Clinical Trials Session at the American College of Cardiology 66th Annual Scientific Session in Washington, D.C. People with naturally occurring mutations in the PCSK9 gene have unusually low levels of bad cholesterol-and up to an 88% lower risk of developing heart disease. However, there are some deus which are prescribed to the patients with high levels of cholesterol but the cost of some them are really high.

But they were approved only for those with a genetic condition that means they have dangerously high cholesterol, and people with heart disease who can not cope with the side effects of statins. The data from Amgen's "Fourier" study are meant to prove to insurers and clinicians that evolocumab is worth its $14,000 per month list price, which was met with major resistance.

This treatment has not been approved for all kind of patients.

"As a practicing cardiologist who sees a lot of patients with severe dyslipidemia and/or statin intolerance, I am very excited by these data because I need all the tools I can get to reduce CVD risk, especially for patients with severe dyslipidemia or who can't tolerate statins, " Stein wrote in an email.

Many doctors said that the results from the medicine were a major achievement in the heart conditions.

Repatha is a human monoclonal antibody, which supressess proprotein convertase subtilisin/kexin type 9 (PCSK9).

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In the study, researchers gave 497 patients with high cholesterol and at high risk of cardiovascular disease either inclisiran at varying doses, or placebo.

According to the Centers for Disease Control and Prevention, around 610,000 people die each year in the United States as a effect of heart disease.

Evolocumab is a human monoclonal antibody that works by blocking a protein that reduces the liver's ability to remove LDL cholesterol from the blood, called PCSK9.

Amgen's scientists have developed Repatha by interacting PCSK9 and the LDL receptor (LDLR), including the site where the LDLR binds to PCSK9.

Another study focused on evolocumab's effects on the cognitive function showed that there was no difference between the placebo group and the patients receiving evolocumab in the working memory, memory function and psychomotor speed.

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